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Influences gistaminozavisimuyu step allergic reactions by inhibiting eotaxin facilitate transendothelial migration of eosinophils by blocking the expression of vascular cell adhesion molecule 1, reduces migration of eosinophils, vascular permeability reduces, limits release of inflammatory mediators. It prevents the primobolan acetateĀ development and facilitates the allergic reaction has antiexudativ, antipruritic action, virtually no anticholinergic and antiserotoninovogo action….

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Relationship to plasma proteins – 30-40%. It penetrates the tissues and organs: lungs, bronchial mucosa, sputum, organs of the urogenital system, polymorphonuclear leukocytes, alveolar macrophages. Antibiotic concentration in the skin 2 times, and in the lungs – from 2 to 5 times higher than serum. The volume of distribution after i / v infusion of…

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No dose adjustment is required in patients with impaired hepatic function. Side effect From the digestive system : nausea, vomiting, diarrhea, loss of appetite, abdominal pain, pseudomembranous colitis, increased activity of “liver” transaminases, hyperbilirubinemia, hepatitis, dysbiosis. Since the cardiovascular system : blood pressure, QT prolongation , circulatory collapse, tachycardia, rarely – atrial fibrillation. metabolism :…