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Penile erection is a hemodynamic process based on the relaxation of smooth muscles of cavernous bodies and located in its arterioles. During sexual stimulation of the nerve endings of the cavernous bodies released nitric oxide (N0), activating the enzyme guanylate cyclase, resulting in increased content in the cavernous bodies of cyclic guanosine monophosphate (cGMP). The…

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Ondansetron is a selective 5-HT receptor antagonist 3 (serotonin). Cytostatic drugs for chemotherapy and radiotherapy may cause an increase in the level of serotonin, which by activation of vagal afferent fibers containing receptors 5-HT 3 causes the gag reflex.Ondansetron inhibits occurrence gag reflex by blockade of 5-HT receptor 3 neuronal level both central and peripheral…

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After application of the active substance accumulation in the epidermis, mainly. in the granular layer. The metabolism ofhydrocortisone butyrate absorbed through the skin, is metabolized to hydrocortisone and other metabolites directly in the epidermis and in the future, in the liver.Excretion of Metabolites and a small portion of unchanged hydrocortisone butyrate excreted by the kidneys…

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The drug reduces the intraocular pressure (IOP) by increasing the outflow of aqueous humor through the uveoscleral mostly and through the trabecular meshwork. Lowering IOP starts approximately 3-4 hours after administration, the maximum effect is observed after 8-12 hours, the effect persists for at least 24 hours. It was established that latanoprost has no significant…