No dose adjustment is required in patients with impaired hepatic function.
Side effect From the digestive system : nausea, vomiting, diarrhea, loss of appetite, abdominal pain, pseudomembranous colitis, increased activity of “liver” transaminases, hyperbilirubinemia, hepatitis, dysbiosis. Since the cardiovascular system : blood pressure, QT prolongation , circulatory collapse, tachycardia, rarely – atrial fibrillation. metabolism : hypoglycemia (increased appetite, sweating, nervousness, tremors). From the nervous system : headache, primobolan cycle dizziness, weakness, drowsiness, insomnia, paresthesia, anxiety, fear , hallucinations, confusion, depression, movement disorders, convulsions. From the senses : blurred vision, hearing, smell, taste and tactile sensitivity. From the musculoskeletal system : arthralgia, myalgia, myasthenia gravis, tendon rupture, rhabdomyolysis, tendonitis. From the urinary system : hypercreatininemia, interstitial nephritis. From the side of hematopoiesis : eosinophilia, hemolytic anemia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, hemorrhage. Allergic reactions : itching, swelling of the skin and mucous membranes, urticaria, malignant exudative erythema (syndrome Stevens-Johnson), toxic epidermal necrolysis (Lyell’s syndrome), bronchospasm, anaphylactic shock, hypersensitivity pneumonitis, vasculitis. Others – the aggravation of porphyria, photosensitivity, persistent fever, the development of superinfection.
Overdose Symptoms : gastrointestinal disorders (nausea), erosive lesions of the mucous membrane of the gastrointestinal tract, the change interval QT, confusion, dizziness, seizures. Treatment : symptomatic therapy, dialysis is not effective specific antidote is not known.
Interaction with other drugs
The drug increases the half-life of cyclosporin.
With simultaneous use of vitamin K antagonists should be monitored for blood coagulation system.
Cimetidine and drugs that block tubular secretion, slows down.
The effect of reducing drugs that suppress intestinal motility sucralfate, magnesium or aluminum-containing antacids (needed a break between the intake of at least 2 hours) salt ~ of iron and zinc. hypoglycemic agents : strict control of blood glucose levels, since there is a possibility of hyper- and hypoglycemia while using primobolan cycle them with levofloxacin. Nonsteroidal anti-inflammatory drugs and theophylline : when used with levofloxacin increase seizure. Glucocorticosteroids : increase the risk of tendon rupture.
During treatment should avoid sunlight and artificial UV radiation in order to avoid damage to the skin (photosensitivity).
It should be borne in mind that in patients with brain damage history (stroke, major trauma) may develop seizures.
Patients receiving therapy quinolones, including levofloxacin, in rare cases have been observed reaction of immediate type hypersensitivity such as anaphylaxis. If signs of immediate-type hypersensitivity, the drug should be discontinued.
If you suspect pseudomembranous colitis should be lifted immediately levofloxacin and start appropriate treatment. In such cases, you can not use drugs that suppress intestinal motility. Rarely observed when using the drug tendinitis (especially inflammation of the Achilles tendon) may lead to tendon rupture.
Elderly patients are more prone to tendonitis. Glyukortikosteroidami treatment increases the risk of tendon rupture. If tendinitis is suspected, treatment should be discontinued immediately levofloxacin and start appropriate treatment of the affected tendon, for example, providing him rest.
Patients with deficiency of glucose-6-phosphate dehydrogenase can respond to fluoroquinolones destruction of red blood cells (hemolysis). In this regard, treatment of such patients should be levofloxacin with great care. Such side effects of levofloxacin primobolan cycle as dizziness or numbness, drowsiness and visual disturbances may impair the ability to quick reflexes and concentration, which is a certain risk in situations where these abilities are of special importance (eg when driving a car, when servicing machines and mechanisms when working in unstable. buy geneza pharmaceuticals