After application of the active substance accumulation in the epidermis, mainly. in the granular layer. The metabolism ofhydrocortisone butyrate absorbed through the skin, is metabolized to hydrocortisone and other metabolites directly in the epidermis and in the future, in the liver.Excretion of Metabolites and a small portion of unchanged hydrocortisone butyrate excreted by the kidneys and the bile.
Uninfected sensitive primobolan to local glucocorticosteroids, skin conditions with excessive keratinization:
- seborrheic dermatitis;
- atopic dermatitis;
- contact eczema;
- lichen planus.
- Hypersensitivity to the drug;
- bacterial, viral and fungal infections of the skin;
- acne vulgaris, acne rosacea;
- perioral dermatitis;
- postvaktsionalny period;
- violation of the integrity of skin (wounds, ulcers);
- skin tumors;
- syphilitic or tubercular skin lesions;
- Children up to age 6 months, with itching in the anal area – up to 12 years.
diabetes mellitus, tuberculosis (systemic disease). Pregnancy and lactation
Use of the drug Latikort ® in pregnant women is allowed in cases where the assessment of the attending physician the potential benefit to pregnant prevails over potential risk to the fetus. In these cases, the application should be brief and limited to small areas of the skin. Not recommended for use in the I trimester of pregnancy.
During the period of lactation should be applied briefly to the small surface of the skin and does not apply to the breast skin.
Dosage and administration:
Outwardly. In adults : a small amount of the drug is applied to the affected skin 1-3 times a day. Course of treatment 1-3 weeks. The dose of the drug used during the week should not exceed 30-60 g In order to improve the penetration of the drug applied massage. In case of resistance the disease, for example, the localization of dense psoriasis plaques on the elbows, knees, the drug should be used under occlusive dressings. In children : the drug is used with 6 months of age. In children, the suppression of adrenocortical function may develop more quickly. Furthermore, it may observed reduction in the excretion of growth hormone. In applying the drug for a long time is required to observe the body weight, height, level of plasma cortisol. In controlled studies in children who received weekly 30-60 g of ointment primobolan , found no violations of adrenocortical function. When using the drug on the face or under occlusive dressings (diapers, diapers) possibly large extent of absorption, it is recommended to apply the minimum dose drug. Treatment should be short-lived, and under the supervision of a physician.
Side effects are rare and are reversible. Local reactions : seldom – skin irritation. Prolonged use and / or applied to large surfaces, when using occlusive dressings in rare cases aknepodobnye changes, hypopigmentation, miliaria, folliculitis, striae, atrophy skin, hypertrichosis and secondary skin infections. In rare cases, may develop allergic contact dermatitis. Interaction with other means data on drug interactions ointment with other agents are not available.
Data on overdose ointment no. With long-term use of the drug in high doses may cause Cushing’s symptoms.
Treatment: symptomatic against the backdrop of a gradual withdrawal of the drug.
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Avoid getting ointment in the eye. In the case of secondary bacterial or fungal infections is necessary to appoint an external anti-bacterial or anti-fungal agent. With extreme caution should be used drug in the skin of the face due to the possibility of side effects (telangiectasias, atrophy, perioral dermatitis).
If, after 7 days of treatment no improvement or deterioration is observed, as well as in case of resumption of symptoms a few days after the cancellation, use of the drug should be discontinued and consult a doctor. Although the use of high doses for long periods, especially when using occlusive dressings may lead to an increase in the content kortazola plasma is never accompanied by a decrease in reactivity of the pituitary-adrenal system, and removal of the primobolan drug results in a rapid normalization of cortisol production.
With careful use drug existing in cases of atrophic skin conditions, especially in the elderly.
The risk of side effects is lower than when using halogenated steroids.
Latikort ® ointment recommended for subacute inflammatory conditions and lichenification. anabolic steroids online shop
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