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Etoposide is a semisynthetic derivative of podophyllotoxin. The mechanism of action is associated with inhibition of topoisomerase II. Etoposide exerts a cytotoxic effect due to DNA damage. The drug blocks mitosis, causing cell death in the late G2 phase and S-phase mitoticheckogo cycle. High concentrations of the drug in causing cell lysis premitoticheckoy phase. Etoposide…